S125 Potential interactions of CRACM ion channels with the calcium activated potassium channel KCa3.1 in human lung mast cells
نویسندگان
چکیده
منابع مشابه
CRACM/Orai ion channel expression and function in human lung mast cells
BACKGROUND Influx of extracellular Ca(2+) into human lung mast cells (HLMCs) is essential for the FcεRI-dependent release of preformed granule-derived mediators and newly synthesized autacoids and cytokines. However, the identity of the ion channels underlying this Ca(2+) influx is unknown. The recently discovered members of the CRACM/Orai ion channel family that carries the Ca(2+) release-acti...
متن کاملVoltage-dependent and calcium-activated ion channels in the human mast cell line HMC-1.
The mechanisms underlying the recruitment, differentiation, and sustained activation of mast cells in disease are likely to include modulation of ion channels. Specific Ca(2+), K(+), and Cl(-) conductances have been identified in rodent mast cells, but there are no equivalent data on human mast cells. We have used the whole-cell patch-clamp technique to characterize macroscopic ion currents in ...
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of the Dissertation ................................................................................................ ii Acknowledgements ........................................................................................................... iv Dedication ...........................................................................................................................v Table of
متن کاملThe calcium-activated potassium channels of turtle hair cells
A major factor determining the electrical resonant frequency of turtle cochlear hair cells is the time course of the Ca-activated K current (Art, J. J., and R. Fettiplace. 1987. Journal of Physiology. 385:207-242). We have examined the notion that this time course is dictated by the K channel kinetics by recording single Ca-activated K channels in inside-out patches from isolated cells. A hair ...
متن کاملThe Contribution of Orai(CRACM)1 and Orai(CRACM)2 Channels in Store-Operated Ca2+ Entry and Mediator Release in Human Lung Mast Cells
BACKGROUND The influx of extracellular Ca(2+) into mast cells is critical for the FcεR1-dependent release of preformed granule-derived mediators and newly synthesised autacoids and cytokines. The Orai(CRACM) ion channel family provide the major pathway through which this Ca(2+) influx occurs. However the individual role of each of the three members of the Orai channel family in Ca(2+) influx an...
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ژورنال
عنوان ژورنال: Thorax
سال: 2011
ISSN: 0040-6376
DOI: 10.1136/thoraxjnl-2011-201054b.125